Tissue regeneration

corte_2

Regenerating tissue in a multi-scale model using Morpheus software (Starruß et al.,  2014).

In these projects we combine our interest for intra or extracellular signalling pathways with our curiosity on tissue damage related problems. In human beings injuries are in general irreversible, unfortunately. That is, amputation of a leg may lead to wound healing and coagulation processes but not to the member’s regeneration. Nevertheless, certain animals like Axolotl are capable of limb and spinal cord regeneration. Hydra is even extremer: Head amputation generate two separate individuals! If these animals can regenerate their tissues, Why can’t we?

Sub-projects:

1.1 Spinal cord regeneration in the axolotl

1.2 Limb regeneration in the axolotl

1.3 Models of morphogen dynamics in regenerating or developing tissues

1.4 Mechanical model of tissues: Vertex model

 

 

Grants:
  •  Great! ipid4all grant (group2group exchange for academic talents) granted by the Graduate Academy of the Technische Universität Dresden. Project title: “Unravelling the cellular mechanisms during axolotl spinal cord regeneration by a data-driven mathematical modelling approach”. PI: Elly M. Tanaka and E. Albano, 2015.
  • PICT 2014-3469 granted by the National Agency of Scientific and Technological Promotion (ANPCYT) of Argentina. “Mechanisms of regeneration of axolotl the spinal cord: a systems biology approach” $ 252.000. PI: O. Chara. 2015-2017.
  • This project is founded by a Human Frontier Science Program (HFSP) grant.
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