Vestigial dynamics in the developing fruit fly wing

In this project we investigate the long standing problem of determination and control of the final size and shape of developing tissues and organs. In particular, we study the spatiotemporal distribution of the selector gene vestigial (vg) in the primordium of the fruit fly (Drosophila melanogaster) wing, the imaginal wing disc. This gene determines the wing’s cells fate during the development of this tissue. For this purpose, we formulated a multiscale model given by cellular and molecular levels. While Cellular Potts Model (CPM) was considered for the cell level, the concentration of vg was modelled with an ordinary differential equation for each cell that senses the neighbors’ vg concentration. This project is a work in collaboration with the group of Marcos Nahmad, at the Laboratory of Development and Systems Biology at CINVESTAV (Unidad Zacatenco, Mexico city, Mexico).

SysBio members involved:
Osvaldo Chara
H. Ariel Alvarez

Collaborators:
Marcos Nahmad
Luis Muñoz Nava
Carmen Andrés

Fellowships:
Ariel Alvarez got a fellowship from the Secretaría de Ciencia, Tecnología e Innovación de la ciudad de Mexico and the Centro Latinoamericano de Física (SECITI-CLAF), to work in this project at Marcos Nahmad’s Lab.

Luis Muñoz Nava also got a fellowship from the Ministerio de Educación y Deportes de la República Argentina, to work in this project at SysBio.

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