SysBio got the PICT 2017 grant “Signalling cascades versus tissue mechanics as driving forces for tissue regeneration in the axolotl” for the period 2018-2020!
This project is leaded by Osvaldo Chara, involving Tomas Grigera in the responsible group as well as H. Ariel Alvarez, Emanuel Cura Costa, Alberto Ceccarelli, Augusto Borges, Vanessa Vidal, Leticia Rubio-Puzzo and Andres DeVirgiliis in the supportive group.
June 5, 2018
A new paper revealing a signalling mechanism controlling the apical membrane size in neuroepithelial rosettes was published in Stem Cell Reports, in a collaborative project leaded by Elly M. Tanaka, from the IMP in Vienna and involving Jan-Philip Medelnik, from IMP and Osvaldo Chara, from SysBio.
May 3, 2018
A science popularization article was published today in the CONICET’s website, in the CCT La Plata site and in the University of La Plata site describing our last article unveiling the mechanism of DNA segregation by a molecular motor published in Scientific Reports.
May 1, 2018
April 16, 2018
A new paper reporting how a molecular motor regulates the direction of chromosome transport was published by SysBio members Osvaldo Chara and Augusto Borges ! This was a collaboration between our group and Marcelo Nöllman’s group in CBS, Montpellier. Read more.
March 26, 2018
Alberto Ceccarelli graduated at the University of La Plata defending his MSc in Physics entitled: “Dynamical and structural study of tissues: a vertex model approach” under the direction of Osvaldo Chara and codirected by Ariel Alvarez at SysBio.
Congratulations Alberto! Well done!
Alberto Ceccarelli got the CONICET PhD fellowship in strategic subjects to study mechanical and signaling aspects of regeneration processes in spinal cord of the axolotl in SysBio.
November 14, 2017
Osvaldo was interviewed at the radio program El tornillo de Arquímedes
Luis Manuel Muñoz Nava is visiting our Lab from October to December 2017. Luis is a PhD student from the Laboratory of Development and Systems Biology at CINVESTAV (Mexico), and we are currently studying together the recruitment mechanism of the selector gene vestigial in the imaginal wing disc of Drosophila melanogaster.
We hope you enjoy your trip Luis!
August 4, 2017
A PhD is not an easy task at all. It takes sweat, tears and a lot of coffee. Congratulations Fabian Rost! Best wishes for this important milestone in your life and career.
Greeting for his doctoral advisors Elly Tanaka, Osvaldo Chara and Lutz Brusch as well!
Baptiste Guilhas, PhD student from the Mechanisms of DNA segregation and remodeling group at the Center of Structural Biochemistry, in Montpellier, France is visiting SysBio to investigate how DNA plasmids are actively segregated by specialized machineries in Escherichia Coli, in the framework of a collaboration funded by the joint grant ECOS A16B01.
We hope you enjoy your stay in Argentina Baptiste!
Augusto Borges is staying at the Nöllmann lab, in Montpellier, France in the framework of our ECOS SUD funded project A16B01 (entitled “Dissecting the molecular mechanism of bacterial DNA translocases”).
Learn, work and enjoy as much as you can, Augusto!
The 1st Latin American Workshop and Conference on Systems Biology co-organized by SysBio made its way into the mexican CINVESTAV news! Here’s the Article.
May 6-14, 2017
H. Ariel Alvarez did a scientific stage at Marcos Nahmad’s Lab in CINVESTAV (Mexico).
May 2-5, 2017
Osvaldo Chara, H. Ariel Alvarez and Emanuel Cura Costa co-organized the 1st Latin American Workshop and Conference on Systems Biology which took place at Mexico City.
Osvaldo gave a lecture at the workshop on “Reaction-Diffusion, Cell-based and Multi-Scale models” and a talk at the conference on “Mechanisms of tissue regeneration in the axolotl”. Ariel gave a Flash talk at the conference on “Recruitment shapes the spatio-temporal distribution of the Vestigial domain in Drosophila wing disc”.
During the Workshop, Osvaldo, Ariel and Emanuel organized the Hands-On Lab about “Numerical Integration of Differential Equations” and “Multiscale Modelling”. See more details in Events.
April 19, 2017
Yesterday we had our first SysBio Retreat in Buenos Aires.
First we had a workshop on our work at the School of Medicine of the University of Buenos Aires (UBA) and later both, recreation activities and scientific discussions at the Bellas Artes museum and trekking along the Ecological Reservation.
We had a great time together! Here’s the schedule of the retreat.
March 14, 2017
Today is visiting SysBio Dr. Julieta Aprea, postdoctoral researcher from the group of Proliferation and Differentiation of Neural Stem Cells, leaded by Prof. Dr. Federico Calegari at the DFG-Center for Regenerative Therapies Dresden,
Technische Universität Dresden (CRTD), Germany.
March 2, 2017
A science popularization article was published today in the CONICET’s website, sharing our article “Acceleration of cell cycle driving spinal cord regeneration“ (the central headline of eLife) and our article “Live Imaging of Axolotl digit regeneration reveals spatiotemporal choreography of diverse connective tissue progenitor pools” (see link here) which was the cover of Developmental Cell.
December 28, 2016
Today, our paper on acceleration of cell cycle driving spinal cord regeneration
December 23, 2016
December 7, 2016
November 16, 2016
Emanuel Cura Costa is visiting the Technische Universität Dresden investigating autoinmune diseases at Prof. Min Ae Lee-Kisrsch’s lab and studying axolotl spinal cord regeneration by using different kind of modelling approaches.
Work hard and enjoy Dresden!
SysBio published a new article!
Fantastic spatiotemporal choreography of connective tissue progenitor cells during axolotl digit regeneration
The process of blastema formation (the key, distinctive feature of regenerating limbs) has so far suffered from a lack of mechanistic understanding. The identity of the cells forming the blastema and the particular cellular response (cell proliferation, cell migration, …) triggered during the regenerative process remained yet unclear.
SysBio participated in this interdisciplinary and international study which represents the first, live imaging of connective tissue cells at single cell resolution during axolotl limb regeneration. The article was published this month in Dev Cell and the link can be found in here.
We investigated the dynamics of volume change of plant cell vacuoles (which occupy up to 90 % of the cell volume) under progressively applied osmotic gradients.
When aquaporins are present, it is accepted that initial volume changes are only due to water movements. However, in living cells osmotic changes are not necessarily abrupt but gradually imposed. Under these conditions, water flux might not be the only relevant driving force shaping the vacuole volume response. In this study, we quantitatively investigated volume dynamics of isolated Beta vulgaris root vacuoles under progressively applied osmotic gradients at different pH.
Our findings indicate that vacuole volume changes, under progressively applied osmotic gradients, would not depend on the membrane elastic properties, nor on the non-osmotic volume of the vacuole, but on water and solute fluxes across the tonoplast. This is relevant in many plant organs such as root, leaves, cotyledons, or stems that perform extensive rhythmic growth movements, which very likely involve considerable cell volume changes within seconds to hours.
We investigated a pathology known as Familial chilblain lupus, which is a monogenic form of cutaneous lupus erythematosus caused by loss-of-function mutations in the nucleases TREX1 or SAMHD1. In a family without TREX1 or SAMHD1 mutation, we sought to determine the causative gene and the underlying disease pathology. By combining clinical, experimental and modelling approaches we found that a heterozygous gain-of-function mutation in the protein known as STING can cause familial chilblain lupus.
This work is one of the outcomes of a collaboration with the Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Germany and is being funded by the great! ipid4all grant (group2group exchange for academic talents) from the Graduate Academy of the Technische Universität Dresden.
SysBio got the the great! ipid4all grant (group2group exchange for academic talents) from the Graduate Academy of the Technische Universität Dresden in 2016 for the project entitled “Combining clinical, experimental and modelling approaches to investigate the effects of a mutation in STING causing Familial Chilblain Lupus”.
In SysBio we are seeking for students interested in a Postdoctoral position in tissue regeneration studied by a Systems Biology approach
We offer a postdoctoral position granted from CONICET in the field of tissue regeneration by using Systems Biology approaches involving quantitative data analysis, statistics and mathematical modelling. The postdoc position would involve to work in an interdisciplinary group having strong links with experimental groups of Argentina and abroad.
Working place: Buenos Aires (CABA) or La Plata.
Deadline: until August 8, 2016.
Requirements: Strong motivation to participate in this wonderful adventure of basic sciences. Interest in interdisciplinary work (e.g., if you are biologist and you want to learn math or programming, or if you are a physicist and you would like to learn developmental biology). To be able to travel between Argentina and Europe is a bonus. Excellent level of English.
Founding: CONICET postdoctoral fellowship.
Contact: Dr. Osvaldo Chara, group leader of SysBio
June 29, 2016
SysBio published a paper on Dynamic Regulation of Cell Volume and Extracellular ATP of Human Erythrocytes (PLoS ONE).
April 15, 2016
You can see more interviews in “IN THE MEDIA” section at the left panel!
February 11, 2016
Hans Meinhardt passed away
February 7, 2016
Our recent publication on PCP signaling during axolotl spinal cord regeneration made it into the headlines of the eLife website: http://elifesciences.org/
January 7, 2016
Work hard and enjoy México Ariel!
December 30, 2015
SysBio published a paper on Cooperativity in Binding Processes (PLoS ONE).
December 22, 2015
Lisandro Milocco graduated at the University of La Plata defending his thesis entitled
“Signalling during tissue regeneration: a systems biology approach” under the direction of Osvaldo Chara in SysBio.
Congratulations Lisandro! Good job!!!
December 5, 2015
SysBio participated in the Latin American Conference on Mathematical Modeling of Biological Systems
December 1-4, Buenos Aires, Argentina.
H. Ariel Alvarez participated in a poster entitled “Fractal cell volume regulation”
Augusto Borges participated in a poster entitled “Dynamics of interaction between the molecular motor SpoIIIE and DNA”
Alberto Ceccarelli participated in a poster entitled “Mechanical regulation of water permeability in cells: a modelling study”
Some pics of the event here.
December 1, 2015
November 30, 2015
SysBio participated in the Latin American Crosstalk in Biophysics and Physiology. SBF.uy-SAB.
November 26-29, 2015. Salto, Uruguay.
Osvaldo Chara gave a talk entitled: “Axolotl spinal cord regeneration triggered by cell proliferation: a quantitative biology approach” in the Symposium of Biomechanics and Complex Systems.
Some pics of the event here.
November 30, 2015
Osvaldo Chara got promoted! Now he is an Independent Researcher (“investigador Independiente” in Spanish) from the National Scientific and Technical Research Council (Spanish: Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET).
November 20, 2015
SysBio published an article in eLife on the role of planar cell polarity pathway on the neural stem cell expansion during axolotl spinal cord regeneration.
November 18, 2015
You can see some pics here.
November 6, 2015
June 17, 2015
June 2, 2015
Lisandro Milocco started his undergraduate thesis in SysBio working on Mathematical modelling of regenerative processes!
June 1, 2015
May 5, 2015
Dr. H. Ariel Alvarez from SysBio got a fellowship from SECITI-CLAF devoted to a postdoctoral stage in the group of Marcos Nahmad Bensusan, in DF, Mexico! for working on the inter-cell mechanical interactions for the control of organ growth during development.
April 1, 2015
Emanuel Cura Costa started his Ph. D. in SysBio with a fellowship from the National Scientific and Technical Research Council (Spanish: Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET) to work on Tissue regeneration, a systems biology approach!
Welcome on Board, Emanuel!