April, 2019

Dr. Juan Fernandez started his post-doctoral fellowship from CONICET at SysBio !
Juan is a physician (University of Buenos Aires) who did his PhD in the Department of Physiology and Biophysics, School of Medicine, University of Buenos Aires. Later he did his medical residency together with his specialization in Cardiology ending up being selected as the chief of residents of the Britannic Hospital in Buenos Aires. Juan teaches as well physiology and biophysics in the aforementioned School of Medicine. His postdoc will open up a new line in our team to investigate cardiac electrical activity by means of new applications of electrocardiography and vectorcardiography with special emphasis in cardiac syncrony evaluation and arrhythmia diagnosis and treatment.

February-March, 2019

We are looking for a talented candidate for a PhD to work in a fascinating problem of tissue development and regeneration with ANPCyT funding starting on April-May 2019.
Interested candidates contact Osvaldo Chara (
More information (in spanish) in this link.

November-December, 2018

Dr. Victoria Tüngler, from the Klinik f. Kinder- u. Jugendmedizin, (Universitätsklinikum C.G. Carus, Technische Universität Dresden, Germany), visited SysBio to work with us in our joint project regarding molecular mechanisms of monogenic pediatric autoinflammatory diseases funded by the Graduate Academy of the Technische Universität Dresden.
Our motto: Run Molecular Dynamics Simulations, Run!

November, 2018

Augusto Borges got his MSc in Physics!

Augusto graduated at the University of La Plata defending his MSc in Physics entitled: “Study of DNA segregation: A Monte Carlo approach” under the direction of Osvaldo Chara at SysBio and codirected by Diego Cattoni at CBS, INSERM, CNRS, Montpellier, France).

August, 2018

Sören Reinke was visiting SysBio

Sören Reinke, PhD student from the lab of Prof. Dr. med. Angela Rösen-Wolff (Klinik f. Kinder- u. Jugendmedizin, Universitätsklinikum C.G. Carus, Technischen Universität Dresden, Germany) visited SysBio in the framework of our project entitled “Molecular mechanisms of STING function and dysfunction in monogenic pediatric vascular autoinflammatory diseases” granted by the Great! ipid4all grant, Graduate Academy of the Technische Universität Dresden.
Hope you enjoyed La Plata and Argentina, Sören!

July, 2018

SysBio at the ECMTB 2018!

Osvaldo Chara was invited by Diane Peurichard  and Dirk Drasdo  to the mini-Symposium of “Exploring the tissue regeneration processes through mathematical modelling” at the European Conference of Mathematical and Theoretical Biology (ECMTB) held in Lisbon.

foto 1

A number n of mathematical biologists attended to the conference, where n >> 100!

foto 2

Haralampos (Babis) Hatzikirou (Helmholtz Institute for Infection Research, Brunswick, Germany), Osvaldo Chara (SysBio, La Plata, Argentina) and Yannis Kalaidzidis (Zerial group, Max Planck of Cell Biology and Genetics, Dresden, Germany).

foto 3

Discussions between Yannis Kalaidzidis (Zerial group, Max Planck of Cell Biology and Genetics, Dresden, Germany) and Osvaldo Chara enthusiastically continued over dinner!

July, 2018

Interesting discussions on regeneration models at the Helmholtz Zentrum München! Osvaldo Chara was invited by Hernán López-Schier to give a seminar on “Spatiotemporal distribution of cell proliferation along the axolotl spinal cord during regeneration”. Later discussions went on with Elba Raimúndez-Álvarez, Dr. Prisca Chapouton, Dr. Carsten Marr and continued over dinner with the Osvaldo, Dr. Carsten Marr, the host and Eva Kozak (left to right in the picture) and by Skype with Dr. Jan Hasenauer. Thank you all for the enriching exchange of promising ideas!
foto 0
Osvaldo Chara, Carsten Marr, Hernán López-Schier and Eva Kozak (from left to right)

June, 2018

Interviews with Elly Tanaka!
Two interviews with our collaborator Prof. Dr. Elly M. Tanaka were recently published in Development and in the Int J Dev Biol!

June, 2018

SysBio got the PICT 2017 grant “Signalling cascades versus tissue mechanics as driving forces for tissue regeneration in the axolotl” for the period 2018-2020!

This project is leaded by Osvaldo Chara, involving Tomas Grigera in the responsible group as well as H. Ariel Alvarez, Emanuel Cura Costa, Alberto Ceccarelli, Augusto Borges, Vanessa Vidal, Leticia Rubio-Puzzo and Andres DeVirgiliis in the supportive group.

June 5, 2018

A new paper revealing a signalling mechanism controlling the apical membrane size in neuroepithelial rosettes was published in Stem Cell Reports, in a collaborative project leaded by Elly M. Tanaka, from the IMP in Vienna and involving Jan-Philip Medelnik, from IMP and Osvaldo Chara, from SysBio.

Read more.

May 3, 2018

A science popularization article was published today in the CONICET’s website, in the CCT La Plata site and in the University of La Plata site describing our last article unveiling the mechanism of DNA segregation by a molecular motor published in Scientific Reports.

May 1, 2018

Article by Augusto Borges and Osvaldo Chara in CienciaNet describing our recent paper in Scientific Reports

April 16, 2018

A new paper reporting how a molecular motor regulates the direction of chromosome transport was published by SysBio members Osvaldo Chara and Augusto Borges ! This was a collaboration between our group and Marcelo Nöllman’s group in CBS, Montpellier. Read more.

Screenshot from 2018-04-12 16-44-51

March 26, 2018

Alberto Ceccarelli graduated at the University of La Plata defending his MSc in Physics entitled: “Dynamical and structural study of tissues: a vertex model approach” under the direction of Osvaldo Chara and codirected by Ariel Alvarez at SysBio.

Congratulations Alberto! Well done!

February, 2018

Dr. Diego I. Cattoni from the DNA segregation and Remodeling Team, at the Centre de Biochimie Structurale (INSERM/CNRS/Université de Montpellier), France is staying in SysBio. He is working with us in our project entitled “Dissecting the  molecular mechanism  of  bacterial DNA translocases”, funded by ECOS-Sud from France and Argentina.

Welcome Diego!

December, 2017

Alberto Ceccarelli got the CONICET PhD fellowship in strategic subjects to study mechanical and signaling aspects of regeneration processes in spinal cord of the axolotl in SysBio.

Congratulations Beto!!

November 14, 2017

Osvaldo was interviewed at the radio program El tornillo de Arquímedes

Here’s the link to the interview: Axolotl is a fantastic animal.

October-December, 2017

Luis Manuel Muñoz Nava is visiting our Lab from October to December 2017. Luis is a PhD student from the Laboratory of Development and Systems Biology at CINVESTAV (Mexico), and we are currently studying together the recruitment mechanism of the selector gene vestigial in the imaginal wing disc of Drosophila melanogaster.

We hope you enjoy your trip Luis!

August 4, 2017

A PhD is not an easy task at all. It takes sweat, tears and a lot of coffee.  Congratulations Fabian Rost!  Best wishes for this important milestone in your life and career.

Greeting for his doctoral advisors Elly Tanaka, Osvaldo Chara and Lutz Brusch as well!

Find the thesis in here.

August, 2017

Baptiste Guilhas, PhD student from the Mechanisms of DNA segregation and remodeling group at the Center of Structural Biochemistry, in Montpellier, France is visiting SysBio to investigate how DNA plasmids are actively segregated by specialized machineries in Escherichia Coli, in the framework of a collaboration funded by the joint grant ECOS A16B01.

We hope you enjoy your stay in Argentina Baptiste!

June, 2017

Augusto Borges is staying at the Nöllmann lab, in Montpellier, France in the framework of our ECOS SUD funded project A16B01 (entitled “Dissecting the molecular mechanism of bacterial DNA translocases”).
Learn, work and enjoy as much as you can, Augusto!

May, 2017

The 1st Latin American Workshop and Conference on Systems Biology co-organized by SysBio made its way into the mexican CINVESTAV news! Here’s the Article.

May 6-14, 2017

H. Ariel Alvarez did a scientific stage at Marcos Nahmad’s Lab in CINVESTAV (Mexico).

May 2-5, 2017

Osvaldo Chara, H. Ariel Alvarez and Emanuel Cura Costa co-organized the 1st Latin American Workshop and Conference on Systems Biology which took place at Mexico City.
Osvaldo gave a lecture at the workshop on “Reaction-Diffusion, Cell-based and Multi-Scale models” and a talk at the conference on “Mechanisms of tissue regeneration in the axolotl”. Ariel gave a Flash talk at the conference on “Recruitment shapes the spatio-temporal distribution of the Vestigial domain in Drosophila wing disc”.
During the Workshop, Osvaldo, Ariel and Emanuel organized the Hands-On Lab about “Numerical Integration of Differential Equations” and “Multiscale Modelling”. See more details in Events.

April 19, 2017

Yesterday we had our first SysBio Retreat in Buenos Aires.

First we had a workshop on our work at the School of Medicine of the University of Buenos Aires (UBA) and later both, recreation activities and scientific discussions at the Bellas Artes museum and trekking along the Ecological Reservation.

We had a great time together! Here’s the schedule of the retreat.

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March 14, 2017

Today is visiting SysBio Dr. Julieta Aprea, postdoctoral researcher from the group of Proliferation and Differentiation of Neural Stem Cells, leaded by Prof. Dr. Federico Calegari at the DFG-Center for Regenerative Therapies Dresden,
Technische Universität Dresden (CRTD), Germany.

March 2, 2017

A science popularization article was published today in the CONICET’s website, sharing our article  “Acceleration of cell cycle driving spinal cord regeneration (the central headline of eLife) and our article “Live Imaging of Axolotl digit regeneration reveals spatiotemporal choreography of diverse connective tissue progenitor pools” (see link here) which was the cover of Developmental Cell.

December 28, 2016

Today, our paper on acceleration of cell cycle driving spinal cord regeneration

(Rost, Rodrigo Albors et al., 2016) became the central headline of eLife.


December 23, 2016

SysBio published a new article in eLife!
SysBio published an article in eLife unveiling the cellular mechanisms triggered during axolotl spinal cord regeneration (Rost, Rodrigo Albors et al., 2016). We previously determined that regenerating stem cells in the axolotl spinal cord revert to a molecular state resembling embryonic neuroepithelial cells and functionally acquire rapid proliferative divisions (Rodrigo Albors et al., 2015). In our recent adventure we investigated whether the acceleration of the cell cycle was sufficient or other cell mechanisms should be also considered. We refined the analysis of cell proliferation in space and time and determined  a high-proliferation zone in the regenerating spinal cord that shifts posteriorly over time. By performing cell tracking we measured cell velocities along the regenerative spinal cord during regeneration. By using a modelling approach, we integrated these quantitative datasets of cell proliferation, neural stem cell activation and cell influx, to predict the tissue outgrowth during regeneration. Our model shows that while cell influx and neural stem cell activation play a minor role, the acceleration of the cell cycle is the major driver of regenerative spinal cord outgrowth in axolotls.

December 7, 2016

Our last article unveiling the choreography of connective tissue triggered during axolotls digit regeneration is now the cover of Dev Cell!

November 16, 2016

Emanuel Cura Costa is visiting the Technische Universität Dresden  investigating  autoinmune diseases at Prof. Min Ae Lee-Kisrsch’s lab and studying axolotl spinal cord regeneration by using different kind of modelling approaches.

Work hard and enjoy Dresden!

November, 2016

SysBio published a new article!

Fantastic spatiotemporal choreography of connective tissue progenitor cells during axolotl digit regeneration

The process of blastema formation (the key, distinctive feature of regenerating limbs) has so far suffered from a lack of mechanistic understanding. The identity of the cells forming the blastema and the particular cellular response (cell proliferation, cell migration, …) triggered during the regenerative process remained yet unclear.
SysBio participated in this interdisciplinary and international study which represents the first, live imaging of connective tissue cells at single cell resolution during axolotl limb regeneration. The article was published this month in Dev Cell and the link can be found in here.

October, 2016

SysBio published a new article!
We investigated the dynamics of volume change of plant cell vacuoles (which occupy up to 90 % of the cell volume) under progressively applied osmotic gradients.
When aquaporins are present, it is accepted that initial volume changes are only due to water movements. However, in living cells osmotic changes are not necessarily abrupt but gradually imposed. Under these conditions, water flux might not be the only relevant driving force shaping the vacuole volume response. In this study, we quantitatively investigated volume dynamics of isolated Beta vulgaris root vacuoles under progressively applied osmotic gradients at different pH.
We followed the vacuole volume changes while simultaneously determining the external osmolality time-courses and analyzing these data with mathematical modeling.
Our findings indicate that vacuole volume changes, under progressively applied osmotic gradients, would not depend on the membrane elastic properties, nor on the non-osmotic volume of the vacuole, but on water and solute fluxes across the tonoplast. This is relevant in many plant organs such as root, leaves, cotyledons, or stems that perform extensive rhythmic growth movements, which very likely involve considerable cell volume changes within seconds to hours.

September, 2016

SysBio published a new article!
We investigated a pathology known as Familial chilblain lupus, which is a monogenic form of cutaneous lupus erythematosus caused by loss-of-function mutations in the nucleases TREX1 or SAMHD1. In a family without TREX1 or SAMHD1 mutation, we sought to determine the causative gene and the underlying disease pathology. By combining clinical, experimental and modelling approaches we found that a heterozygous gain-of-function mutation in the protein known as STING can cause familial chilblain lupus.
This work is one of the outcomes of a collaboration with the Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Germany and is being funded by the great! ipid4all grant (group2group exchange for academic talents) from the Graduate Academy of the Technische Universität Dresden.

August, 2016

SysBio got the the great! ipid4all grant (group2group exchange for academic talents) from the Graduate Academy of the Technische Universität Dresden in 2016 for the project entitled “Combining clinical, experimental and modelling approaches to investigate the effects of a mutation in STING causing Familial Chilblain Lupus”.

July-August, 2016

In SysBio we are seeking for students interested in a Postdoctoral position in tissue regeneration studied by a Systems Biology approach

We offer a postdoctoral position granted from CONICET in the field of tissue regeneration by using Systems Biology approaches involving quantitative data analysis, statistics and mathematical modelling. The postdoc position would involve to work in an interdisciplinary group having strong links with experimental groups of Argentina and abroad.
Working place: Buenos Aires (CABA) or La Plata.
Deadline: until August 8, 2016.
Requirements: Strong motivation to participate in this wonderful adventure of basic sciences. Interest in interdisciplinary work (e.g., if you are biologist and you want to learn math or programming, or if you are a physicist and you would like to learn developmental biology). To be able to travel between Argentina and Europe is a bonus. Excellent level of English.

Founding: CONICET postdoctoral fellowship.
Contact: Dr. Osvaldo Chara, group leader of SysBio

 June 29, 2016

SysBio published a paper on Dynamic Regulation of Cell Volume and Extracellular ATP of Human Erythrocytes (PLoS ONE).

Here the link

 April 15, 2016

Osvaldo was interviewed (spanish) by the press department of CONICET.

You can see more interviews inIN THE MEDIA” section at the left panel!

February 11, 2016

Hans Meinhardt passed away

Read more

February 7, 2016

Our recent publication on PCP signaling during axolotl spinal cord regeneration made it into the headlines of the eLife website:

Here a digest!

January 7, 2016

Ariel Alvarez is performing a scientific stage at Dr. Nahmad lab to study developmental processes in Drosophila melanogaster imaginal discs by using mathematical modelling.

Work hard and enjoy México Ariel!

December 30, 2015

SysBio published a paper on Cooperativity in Binding Processes (PLoS ONE).

Here the link

December 22, 2015

Lisandro Milocco graduated at the University of La Plata defending his thesis entitled
Signalling during tissue regeneration: a systems biology approach” under the direction of Osvaldo Chara in SysBio.

Congratulations Lisandro! Good job!!!

December 5, 2015

SysBio participated in the Latin American Conference on Mathematical Modeling of Biological Systems
December 1-4, Buenos Aires, Argentina.

H. Ariel Alvarez participated in a poster entitled “Fractal cell volume regulation”

Emanuel Cura Costa and Lisandro Milocco participated in a poster entitled “Crosstalk of cells and signalling processes during tissue regeneration: a data-driven modelling approach”

Augusto Borges participated in a poster entitled “Dynamics of interaction between the molecular motor SpoIIIE and DNA”

Alberto Ceccarelli participated in a poster entitled “Mechanical regulation of water permeability in cells: a modelling study”

Some pics of the event here.

December 1, 2015

Ariel and Emanuel got a grant from CELFI (Centro Latinoamericano de formación Interdiciplinaria) to attend to the Latin American Conference on Mathematical Modeling of Biological Systems.

Congratulations guys!

November 30, 2015

SysBio participated in the Latin American Crosstalk in Biophysics and Physiology.
November 26-29, 2015. Salto, Uruguay.

Osvaldo Chara gave a talk entitled: “Axolotl spinal cord regeneration triggered by cell proliferation: a quantitative biology approach” in the Symposium of Biomechanics and Complex Systems.

Some pics of the event here.

November 30, 2015

Osvaldo Chara got promoted! Now he is an Independent Researcher (“investigador Independiente” in Spanish) from the National Scientific and Technical Research Council (Spanish: Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET).

Congratulations Osvaldo!

November 20, 2015

SysBio published an article in eLife on the role of planar cell polarity pathway on the neural stem cell expansion during axolotl spinal cord regeneration.

November 18, 2015

We ‘ve finished the workshop “Hands-on Morpheus” by Fabian Rost.
We really enjoyed it!
Now, it’s “asado” time!

You can see some pics here.

November 6, 2015

We have the pleasure to receive Fabian Rost in Argentina.
Hope you have a very productive and enjoyable stay!

June 17, 2015

SysBio got the great! ipid4all grant (group2group exchange for academic talents) from the Graduate Academy of the Technische Universität Dresden for intensively working on “Unravelling the cellular mechanisms during axolotl spinal cord regeneration by a data-driven mathematical modelling approach” during 2015.

June 2, 2015

Lisandro Milocco started his undergraduate thesis in SysBio working on Mathematical modelling of regenerative processes!

June 1, 2015

SysBio got the PICT 2014 grant “Mechanisms of regeneration of the axolotl spinal cord: a systems biology approach” for the period 2015-2017!

May 5, 2015

Dr. H. Ariel Alvarez from SysBio got a fellowship from SECITI-CLAF devoted to a postdoctoral stage in the group of Marcos Nahmad Bensusan, in DF, Mexico! for working on the inter-cell mechanical interactions for the control of organ growth during development.

Congratulations, Ariel!

April 1, 2015

Emanuel Cura Costa started his Ph. D. in SysBio with a fellowship from the National Scientific and Technical Research Council (Spanish: Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET) to work on Tissue regeneration, a systems biology approach!

Welcome on Board, Emanuel!



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